| 2021-08-07 14:30:35August 7, 2021 | Tata Steel RFC v Neath | 14:30:35Cancelled | WRU Championship Cup | 2021-22 | Tata Steel Sports Ground | Recap | - |
| 2021-08-14 14:30:58August 14, 2021 | Maesteg Quins RFC v Neath | 32 - 23 | WRU Championship Cup | 2021-22 | South Parade | Recap | - |
| 2021-08-20 19:15:04August 20, 2021 | Neath v Birchgrove RFC | 19:15:04Cancelled | Friendly | 2021-22 | The Lextan Gnoll | Recap | - |
| 2021-08-25 19:15:46August 25, 2021 | Gilfach Goch v Neath | 13 - 60 | Friendly | 2021-22 | The Welfare Park | Recap | - |
| 2021-09-04 14:30:11September 4, 2021 | Neath v Maesteg Quins RFC | 13 - 16 | WRU Championship Cup | 2021-22 | The Lextan Gnoll | Recap | - |
| 2021-09-11 14:30:36September 11, 2021 | Neath v Swansea | 14 - 17 | Friendly | 2021-22 | The Lextan Gnoll | Recap | - |
| 2021-09-18 14:30:33September 18, 2021 | Neath v Tata Steel RFC | 36 - 20 | WRU Championship Cup | 2021-22 | The Lextan Gnoll | Recap | - |
| 2021-09-24 19:15:33September 24, 2021 | Bryncethin v Neath | 0 - 36 | Friendly | 2021-22 | Away | Recap | - |
| 2021-10-09 14:30:12October 9, 2021 | Narberth v Neath | 7 - 19 | WRU Championship Cup | 2021-22 | Lewis-Lloyd Ground | Recap | - |
| 2021-10-16 14:30:27October 16, 2021 | Ystrad Rhondda v Neath | 25 - 31 | WRU Championship Cup | 2021-22 | Gelligaled Park | Recap | - |
| 2021-10-23 14:30:49October 23, 2021 | Neath v Glamorgan Wanderers | 45 - 5 | WRU Championship Cup | 2021-22 | The Lextan Gnoll | Recap | - |
| 2021-11-04 19:15:53November 4, 2021 | Mountain Ash v Neath | 20 - 21 | Friendly | 2021-22 | Duffryn Pennar Park | Recap | - |
| 2021-11-13 14:30:47November 13, 2021 | Narberth v Neath | 22 - 30 | Championship | 2021-22 | Lewis-Lloyd Ground | Recap | - |
| 2021-11-19 19:15:29November 19, 2021 | Neath v Glais | 70 - 6 | Friendly | 2021-22 | The Lextan Gnoll | Recap | - |
| 2021-11-27 14:30:44November 27, 2021 | Neath v Pontypool | 9 - 3 | Championship | 2021-22 | The Lextan Gnoll | Recap | - |
| 2021-12-04 14:30:33December 4, 2021 | Trebanos v Neath | 21 - 29 | Championship | 2021-22 | Trebanos Park | Recap | - |
| 2021-12-11 14:30:27December 11, 2021 | Neath v Ystrad Rhondda | 20 - 10 | Championship | 2021-22 | The Lextan Gnoll | Recap | - |
| 2021-12-18 14:30:00December 18, 2021 | Bedwas v Neath | 36 - 30 | Championship | 2021-22 | The Bridgefield | Recap | - |
| 2021-12-26 14:30:08December 26, 2021 | Neath v Kenfig Hill | 14:30:08Postponed | Friendly | 2021-22 | The Lextan Gnoll | Recap | - |
| 2022-01-08 14:30:24January 8, 2022 | Neath v Cross Keys | 14:30:24Postponed | Championship | 2021-22 | The Lextan Gnoll | Recap | - |
| 2022-01-15 14:30:28January 15, 2022 | Neath v Bargoed | 14:30:28Postponed | WRU Championship Cup | 2021-22 | The Lextan Gnoll | Recap | - |
| 2022-01-22 14:30:07January 22, 2022 | Maesteg Quins RFC v Neath | 19 - 34 | Championship | 2021-22 | South Parade | Recap | - |
| 2022-01-29 14:30:42January 29, 2022 | Neath v Bargoed | 20 - 22 | Championship | 2021-22 | The Lextan Gnoll | Recap | - |
| 2022-02-04 19:15:37February 4, 2022 | Swansea v Neath | 21 - 17 | Friendly | 2021-22 | St Helens | Recap | - |
| 2022-02-11 19:15:24February 11, 2022 | Neath v Kenfig Hill | 14 - 15 | Friendly | 2021-22 | The Lextan Gnoll | Recap | - |
| 2022-02-19 14:30:46February 19, 2022 | Neath v Tata Steel RFC | 14:30:46Postponed | Championship | 2021-22 | The Lextan Gnoll | Recap | - |
| 2022-02-24 19:15:45February 24, 2022 | Neath v Central Glamorgan | 39 - 0 | Friendly | 2021-22 | The Lextan Gnoll | Recap | - |
| 2022-03-05 14:30:51March 5, 2022 | Maesteg Quins RFC v Neath | 19 - 25 | WRU Championship Cup | 2021-22 | South Parade | Recap | - |
| 2022-03-12 14:30:01March 12, 2022 | Ystalyfera v Neath | 11 - 19 | Championship | 2021-22 | Ynysydarren Ground | Recap | - |
| 2022-03-26 14:30:11March 26, 2022 | Neath v Beddau | 68 - 14 | Championship | 2021-22 | The Lextan Gnoll | Recap | - |
| 2022-04-09 14:30:17April 9, 2022 | Cardiff Met v Neath | 21 - 29 | Championship | 2021-22 | Cyncoed | Recap | - |
| 2022-04-16 14:30:20April 16, 2022 | Neath v Glamorgan Wanderers | 38 - 31 | Championship | 2021-22 | The Lextan Gnoll | Recap | - |
| 2022-04-24 15:15:50April 24, 2022 | Bargoed v Neath | 13 - 16 | WRU Championship Cup | 2021-22 | Principality Stadium | Recap | - |
| 2022-04-27 19:15:58April 27, 2022 | Neath v Tata Steel RFC | 36 - 20 | Championship | 2021-22 | The Lextan Gnoll | Recap | - |
| 2022-05-06 19:30:24May 6, 2022 | Neath v Cross Keys | 20 - 16 | Championship | 2021-22 | The Lextan Gnoll | Recap | - |
